The teacher series Those Who Can’t is produced by TruTV. Since the series takes place almost exclusively in high school, there are only a few locations. But: the high school building really exists!
The Reed Smoot High School
Even though the series is set in Denver, Colorado, USA, the school building is in California and it is actually a high school as well. The series was actually shot inside the school grounds, even the authors wrote the scripts in a classroom.